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Publications

  • F. Giebel, M. Paulus, J. Nase, I. Kiesel, S. Bieder, M. Tolan, The interaction between stearic acid monolayers and butane under elevated pressures, Colloids and Surfaces A 2016, 504, 126-130
  • P. Schummel, A. Haag, W. Kremer, H. R. Kalbitzer, R. Winter, Cosolvent and Crowding Effects on the Temperature and Pressure Dependent Conformational Dynamics and Stability of Globular Actin, J. Phys. Chem. B 2016, in press
  • S. Puthenpurackal Narayanan, D. Gopalakrishnan Nair, D. Schaal, M. B. Aguiar, S. Wenzel, W. Kremer, S. Schwarzinger, H. R. Kalbitzer, Structural transitions in full-length human prion protein detected by xenon as probe and spin labelling of the N-terminal domain, Scientific Reports 2016, in press
  • R. Frach, P. Kibies, S. Böttcher, T. Pongratz,  S. Strohfeldt, S. Kurrmann, J. Koehler, M. Hofmann, W. Kremer, H. R. Kalbitzer, O. Reiser, D. Horinek, S. M. Kast, The Chemical Shift Baseline for High-Pressure NMR Spectroscopy of Proteins, Angew. Chemie 2016, in press
  • C. Hoelzl, P. Kibies, S. Imoto, R. Frach, S. Suladze, R. Winter, D. Marx, D. Horinek, S. M. Kast, Design Principles for High–Pressure Force Fields: Aqueous TMAO Solutions from Ambient to Kilobar Pressures, J. Chem. Phys. 2016, in press
  • S. Imoto, P. Kibies, C. Rosin, R. Winter, S. M. Kast, D. Marx, Toward Extreme Biophysics: Deciphering the Infrared Response of Biomolecular Solutions at High Pressures, Angew. Chem. Int. Ed., in press
  • M. Beck Erlach, H.-R. Kalbitzer, R. Winter, W. Kremer, Conformational Substates of Amyloidogenic hIAPP Revealed by High Pressure NMR Spectroscopy, ChemistrySelect, in press
  • J. Schulze, J. Möller, J. Weine, K. Julius, N. König, J. Nase, M. Paulus, M. Tolan, R. Winter, "Phase Behavior of Lysozyme Solutions in the Liquid-Liquid Phase Coexistence Region at High Hydrostatic Pressures", PhysChemChemPhys, in press
  • A. Levin, M. Erlkamp, R. Steitz, C. Czeslik, Volume profile of α-chymotrypsin during adsorption and enzymatic reaction on a poly(acrylic acid) brush, Phys. Chem. Chem. Phys. 2016, 18, 9070
  • B. Nowak, M. Paulus, J. Nase, P. Salmen, P. Degen, F. J: Wirkert, V. Honkimäki, M. Tolan, Solid-Supported Lipid Multilayers under High Hydrostatic Pressure, Langmuir 2016, 32 (11),  2638–2643
  • M. Smiechowski, C. Schran, H. Forbert, D. Marx, Correlated Particle Motion and THz Spectral Response of Supercritical Water, Phys. Rev. Lett. 2016, 116, 027801
  • C. Held, G. Sadowski, Compatible solutes: Thermodynamic properties relevant for effective protection against osmotic stress, Fluid Phase Equilibria 2016, 407, 224-235
  • V. Schuabb, S. Cinar, C. Czeslik, Effect of interfacial properties on the activation volume of adsorbed enzymes, Colloids Surf B Biointerfaces 2016, 140, 497–504
  • J. Seeliger, N. Erwin, C. Rosin, M. Kahse, K. Weise, R. Winter, Exploring the structure and phase behavior of plasma membrane vesicles under extreme environmental conditions, Phys. Chem. Chem. Phys. 2015, 17, 7507-7513
  • S. Suladze, S. Cinar, B. Sperlich, R. Winter, Pressure Modulation of the Enzymatic Activity of Phospholipase A2, A Putative Membrane-Associated Pressure Sensor, J. Am. Chem. Soc. 2015, 137, 12588−12596
  • V. P. Voloshin, N. N. Medvedev, N. Smolin, A. Geiger, R. Winter, Exploring volume, compressibility and hydration changes of folded proteins upon compression, Phys.Chem.Chem.Phys. 2015, 17, 8499-8508
  • M. Erlkamp, J. Marion, N. Martinez, C. Czeslik, J. Peters, R. Winter, Influence of Pressure and Crowding on the Sub-Nanosecond Dynamics of Globular Proteins, Phys. Chem.B 2015, 119, 4842-4848
  • S. Imoto, H. Forbert, D. Marx, Water structure and solvation of osmolytes at high hydrostatic pressure: pure water and TMAO solutions at 10 kbar versus 1 bar, Phys. Chem. Chem. Phys. 2015, 17, 24224-24237
  • C. Rosin, K. Estel, J. Hälker, R. Winter, Combined Effects of Temperature, Pressure, and Co-Solvents on the Polymerization Kinetics of Actin, ChemPhysChem. 2015, 16(7), 1379-1385
  • C. Rosin, P. H. Schummel, R. Winter, Cosolvent and crowding effects on the polymerization kinetics of actin, Phys. Chem. Chem. Phys. 2015, 17(13), 8330-8337
  • T. Quan Luong, S. Kapoor, R. Winter, Pressure—A Gateway to Fundamental Insights into Protein Solvation, Dynamics, and Function, ChemPhysChem 2015, 16, 3555–3571
  • M. Gao, R. Winter, Kinetic Insights into the Elongation Reaction of Actin Filaments as a Function of Temperature, Pressure, and Macromolecular Crowding, ChemPhysChem 2015, 16, 3681-3686
  • O. Riechert, T. Zeiner, G. Sadowski, Solvent effects on esterification equilibria, AIChE J.  2015, 61, 3000-3011
  • M. Gao, M. Berghaus, J. von der Ecken, S. Raunser, R. Winter, Condensation Agents Determine the Temperature–Pressure Stability of F-Actin Bundles, Angew. Chem. Int. Ed. 2015, 54, 11088-11092
  • M. Havenith, Solvation Science: A new interdisciplinary field, Angewandte Chemie, Int. Edition 2015, 55(4), 1218-1219
  • L. Knake, G. Schwaab, K. Kartaschew, M. Havenith, Solvation Dynamics of Trimethylamine N-Oxide in Aqueous Solution Probed by Terahertz Spectroscopy, J. Phys. Chem. B 2015, 119(43), 13842-13851
  • E. Decaneto, S. Suladze, C. Rosin, M. Havenith, W. Lubitz, R. Winter, Pressure and Temperature Effects on the Activity and Structure of the Catalytic Domain of Human MT1-MMP, Biophys. J. 2015, 109, 2371
  • S. Imoto, H. Forbert and D. Marx, Water structure and solvation of osmolytes at high hydrostatic pressure: pure water and TMAO solutions at 10 kbar versus 1 bar, Phys. Chem. Chem. Phys. 2015, 17, 24224-24237
  • M. Smiechowski, J. Sun, H. Forbert, D. Marx, Solvation shell resolved THz spectra of simple aqua ions – distinct distance- and frequency-dependent contributions of solvation shells, Phys. Chem. Chem. Phys. 2015, 17, 8323-8329
  • J. Möller, S. Grobelny, J. Schulze, S. Bieder, A. Steffen, M. Erlkamp, M. Paulus, M. Tolan, R. Winter, Reentrant Liquid-Liquid Phase Separation in Protein Solutions at Elevated Hydrostatic Pressures, Phys. Rev. Lett. 2014, 112, 028101
  • C. Held, T. Reschke, R. Müller, W. Kunz, G. Sadowski, Measuring and modeling aqueous electrolyte/amino-acid solutions with ePC-SAFT, J. Chem. Thermodyn. 2014, 68, 1–12
  • M. Sadeghi, C. Held, C. Ghotbi, M.J. Abdekhodaie, G. Sadowski, Thermodynamic Properties of Aqueous Glucose–Urea–Salt Systems, J. Sol. Chem. 2014, 43, 1110-1131
  • J. Koehler, J., Beck Erlach, E. Jr. Crusca, W. Kremer, C. E. Munte, A. Meier, H. R. Kalbitzer, Pressure response of amide one-bond J-couplings in model peptides and proteins, J. Biomol. NMR 2014, 60, 45-50
  • J. Möller, S. Grobelny, J. Schulze, A. Steffen, S. Bieder, M. Paulus, M. Tolan, R. Winter, Specific anion effects on the pressure dependence of the protein–protein interaction potential, Phys.Chem.Chem.Phys. 2014, 16, 7423-7429
  • I. C. Rosnizeck, D. Filchtinski , R. P. Lopes, B. Kieninger, C. Herrmann, H. R. Kalbitzer, M. Spoerner, Elucidating the Mode of Action of a Typical Ras State 1(T) Inhibitor, Biochemistry 2014, 53, 3867−3878.
  • F.J. Wirkert, M. Paulus, J. Nase, J. Möller, S. Kujawski, C. Sternemann, M. Tolan, X-ray reflectivity measurements of liquid/solid interfaces under high hydrostatic pressure conditions, J. Synchrotron Rad. 2014, 21, 76-81
  • J. Sun, G. Niehues, H. Forbert, D. Decka, G. Schwaab, Understanding THz Spectra of Aqueous Solutions: Glycine in Light and Heavy Water, J. Am. Chem. Soc. 2014, 136, 5031-5038
  • C. Rosin, M. Erlkamp, J. von der Ecken, S. Raunser, R. Winter, Exploring the stability limits of actin and its suprastructures, Biophys. J. 2014, 107(12), 2973–2983
  • V. Schuabb, C. Czeslik, Activation Volumes of Enzymes Adsorbed on Silica Particles, Langmuir. 2014, 30, 15496-15503
  • M. Erlkamp, S. Grobelny, R. Winter, Crowding effects on the temperature and pressure dependent structure, stability and folding kinetics of Staphylococcal Nuclease, Phys. Chem. Chem. Phys. 2014, 16, 5965–76
  • M. B. Erlach, J. Koehler, B. Moeser, D. Horinek, W. Kremer, and H. R. Kalbitzer, Relationship between Nonlinear Pressure-Induced Chemical Shift Changes and Thermodynamic Parameters, J. Phys. Chem. B 2014,118, 5681-5690
  • J. Möller, S. Grobelny, J. Schulze, S. Bieder, A. Steffen, M. Erlkamp, M. Paulus, M. Tolan, R. Winter, Reentrant Liquid-Liquid Phase Separation in Protein Solutions at Elevated Hydrostatic Pressures, Phys. Rev. Lett. 2014, 112, 028101
  • P. Hoffmann, C. Held, T. Maskow, G. Sadowski, A thermodynamic investigation of the glucose-6-phosphate isomerization, Biophys. Chem. 2014, 195, 22-31
  • M. Erlkamp, J.-F. Moulin, R. Winter, C. Czeslik, Packing effects of N-Ras binding to a DOPC membrane - a neutron reflectivity and TIRF spectroscopy high-pressure study, Zeitschrift für Physikalische Chemie 2014, 228, 969-986
  • C. Cabrele, T. A. Martinek, O. Reiser, L. Berlicki , Peptides Containing β-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry, J. Med. Chem. 2014, 57, 9718-9739
  • V. Conti Nibali, M. Havenith, New Insights into the Role of Water in Biological Function: Studying Solvated Biomolecules Using Terahertz Absorption Spectroscopy in Conjunction with Molecular Dynamics Simulations, J. Am. Chem. Soc. 2014, 136(37) 12800-12807
  • R. Frach and S. M. Kast, Solvation Effects on Chemical Shifts by Embedded Cluster Integral Equation Theory, J. Phys. Chem. B 2014, 118, 11620-11628
  • J. Möller, S. Grobelny, J. Schulze, A. Steffen, S. Bieder, M. Paulus, M. Tolan, R. Winter, Specific anion effects on the pressure dependence of the protein–protein interaction potential, Phys. Chem. Chem. Phys. 2014, 16, 7423–7429
  • S. Kapoor, M. Berghaus, S. Suladze, D. Prumbaum, S. Grobelny, P. Degen, S. Raunser, R. Winter, Prebiotic Cell Membranes that Survive Extreme Environmental Pressure Conditions, Angew. Chem. Int. Ed. 2014, 53, 8397 –8401
  • J. Sun, G. Niehues, H. Forbert, D. Decka, G. Schwaab, D. Marx, M. Havenith,  Understanding THz Spectra of Aqueous Solutions: Glycine in Light and Heavy Water, J. Am. Chem. Soc. 2014, 136(13), 5031-5038
  • H. R. Kalbitzer, I. C. Rosnizeck, C. E. Munte, S. P. Narayanan, V. Kropf, M. Spoerner, Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High-Pressure NMR Spectroscopy, Angew. Chem. Int. Ed. 2013, 52, 14242–14246
  • E. Schneck, D. Horinek, and R. R. Netz, Insight into the Molecular Mechanisms of Protein Stabilizing Osmolytes from Global Force-Field Variations, J. Phys. Chem. B, 2013, 117, 8310-8321
  • C. E. Munte, M. B. Erlach, W. Kremer, J. Koehler, H. R. Kalbitzer, Distinct Conformational States of the Alzheimer β -Amyloid Peptide can be Detected by High Pressure NMR Spectroscopy, Angew. Chem. Int. Ed. 2013, 52, 8943–8947
  • P. Hoffmann, M. Voges, C. Held, G. Sadowski, The role of activity coefficients in bioreaction equilibria: Thermodynamics of methyl ferulate hydrolysis, Biophys. Chem. 2013, 173–174, 21–30
  • Hoffgaard, J. Heil, and S. M. Kast, Three-Dimensional RISM Integral Equation Theory for Polarizable Solute Models, J. Chem. Theory Comput. 2013, 9, 4718-4726
  • M. Smiechowski, H. Forbert, D. Marx, Spatial decomposition and assignment of infrared spectra of simple ions in water from mid-infrared to THz frequencies: Li(+)(aq) and F(-)(aq), J. Chem. Phys. 2013, 139, 014506
  • F.J. Wirkert, M. Paulus, C. Sternemann, J. Nase, M.A. Schroer, D.C.F. Wieland, S. Bieder, P. Degen, H. Rehage, M. Tolan, Study of time and pressure dependent phenomena at the hard x-ray beamline BL9 of DELTA, J Phys: Conference Series 2013, 425, 202006
  • H. R. Kalbitzer, M. Spoerner, State 1(T) inhibitors of activated Ras, The Enzymes 2013, 33, 69-94
  • T. Harsch, C. Dasch, H.  Donaubauer, K. Baskaran, W. Kremer, H. R. Kalbitzer, Stereospecific Assignment of the Asparagine and Glutamine Side Chain Amide Protons in Random-Coil Peptides by Combination of Molecular Dynamic Simulations with Relaxation Matrix Calculations, Appl. Magn. Reson. 2013, 44, 319-331
  • Ł. Berlicki, M. Kaske, R. Gutiérrez-Abad, G. Bernhardt, O. Illa, R. M. Ortuño, C. Cabrele , A. Buschauer, O. Reiser, Replacement of Thr32 and Gln34 in the C-Terminal Neuropeptide Y Fragment 25–36 by cis-Cyclobutane and cis-Cyclopentane β-Amino Acids Shifts Selectivity toward the Y4 Receptor, J. Med. Chem. 2013, 56, 8422-8431
  • Ł. Berlicki, L. Pilsl, E. Weber, I. M. Mandity, C. Cabrele, T. A. Martinke, F. Fülöp, O. Reiser, Unique α,β- and α,α,β,β-Peptide Foldamers Based on cis-β-Aminocyclopentanecarboxylic Acid, Angew. Chem. Int. Ed. Engl. 2012, 51, 2208-2212
  • J. Koo, C. Czeslik, Probing aggregation and fibril formation of insulin in polyelectrolyte multilayers, Colloids and Surfaces B: Biointerfaces 2012, 94, 80-88
  • C. Held, L.F. Cameretti, G. Sadowski, Measuring and Modeling Activity Coefficients in Aqueous Amino-Acid Solutions, Ind. Eng. Chem. Res. 2011, 50, 131–141
  • F. Evers, C. Reichhart, R. Steitz, M. Tolan, C. Czeslik, Probing adsorption and aggregation of insulin at a poly(acrylic acid) brush, Phys. Chem. Chem. Phys. 2010, 12, 4375-4382
  • C. Held, T. Neuhaus, G. Sadowski, Compatible solutes: Thermodynamic properties and biological impact of ectoines and prolines, Biophys. Chem. 2010, 152, 28–39
  • O. Hollmann, R. Steitz, C. Czeslik, Structure and dynamics of α-lactalbumin adsorbed at a charged brush interface, Phys. Chem. Chem. Phys. 2008, 10, 1448-1456
  • L. Cameretti, G. Sadowski, Modeling of aqueous amino acid and polypeptide solutions with PC-SAFT, Chem. Eng. & Proc. 2008, 47, 1018-1025
  • V. D'Elia, H. Zwicknagl, O. Reiser, Short α/β-Peptides as Catalysts for Intra- and Intermolecular Aldol Reactions, J. Org. Chem. 2008, 73, 3262-3265
  • N. Koglin, C. Zorn, R. Beumer, C. Cabrele, C. Bubert, N. Sewald, O. Reiser, A. G. Beck-Sickinger, Analogues of Neuropeptide Y Containing ß-Aminocyclopropane-carboxylic Acids are the Shortest Linear Peptides Selective for the Y1-Receptor, Angew. Chem. Int. Ed. Engl. 2003, 42, 202-205
  • S. de Pol, C. Zorn, C. Klein, O. Zerbe, O. Reiser, Surprisingly Stable Helical Conformations in α/β-Peptides by Incorporation of cis-β-Aminocyclopropane Carboxylic Acids, Angew. Chem. Int. Ed. Engl. 2004, 43, 511-514
  • J. Gross, G. Sadowski, Perturbed-Chain SAFT:  An Equation of State Based on a Perturbation Theory for Chain Molecules, Ind. Eng. Chem. Res. 2001, 40, 1244-1260