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Publications

ISI profile can be found here (query: Summerer D)

PubMed profile can be found here

 

68. S. Maurer, B. Buchmuller, C. Ehrt, J. Jasper, O. Koch and D. Summerer*

Overcoming Conservation in TALE-DNA Interactions: A Minimal Repeat Scaffold Enables Selective Recognition of an Oxidized 5-Methylcytosine

Chem. Sci., 2018, in press.

 

67. M. Gieß, A. Witte, J. Jasper, O. Koch and D. Summerer*

Complete Programmable Decoding of Oxidized 5-Methylcytosine Nucleobases in DNA by Chemoselective Blockage of Universal Transcription-Activator-Like Effector Repeats

J. Am. Chem. Soc., 2018, 140, 5904-8.

  

66. H. Neumann*, P. Neumann-Staubitz, A. Witte and D. Summerer*

Epigenetic chromatin modification by amber suppression technology

Curr. Opin. Chem. Biol.2018, 45, 1-9.

  

65. M. J. Schmidt, and D. Summerer*

Directed evolution of orthogonal pyrrolysyl-tRNA synthetases in Escherichia coli for the genetic encoding of noncanonical amino acids

Meth. Mol. Biol.2018, 1728, 97-111.

  

64. A. Munoz-Lopez and D. Summerer*

Recognition of Oxidized 5-Methylcytosine Derivatives in DNA by Natural and Engineered Protein Scaffolds

Chem. Rec.2018, 18(1), 105-16.

  

63. P. Rathi, S. Maurer and D. Summerer*

Selective Recognition of N4-Methylcytosine in DNA by Engineered Transcription-Activator-Like Effectors

Philos. Trans. R. Soc. Lond. B Biol. Sci.2018, DOI: 10.1098/rstb.2017.0078.

  

62. P. Rathi, A. Witte and D. Summerer*

Engineering DNA Backbone Interactions Results in TALE Scaffolds with Enhanced 5-Methylcytosine Selectivity

Sci. Rep.2017, (7), 15067.

  

61. S. Flade, J. Jasper, M. Giess, M. Juhasz, A. Dankers, G. Kubik, O. Koch*, E. Weinhold* and D. Summerer*

The N6-Position of Adenine is a Blind Spot for TAL-Effectors that Enables Effective Binding of Methylated and Fluorophore-Labeled DNA

ACS Chem. Biol., 2017, 12 (7), 1719-25.

  

60. S. Maurer, M. Giess, O. Koch and D. Summerer*

Interrogating key positions of size-reduced TALE-repeats reveals a programmable sensor of 5-carboxylcytosine

ACS Chem. Biol., 2016,11 (12), 3294-9.

  

59. Y. J. Lee, M. J. Schmidt, J. M. Tharp, A. Weber, J. Gao, M. L. Waters, D. Summerer* and W. R. Liu*

Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader

Chem. Commun., 2016, 52 (85), 12606-9.

  

58. P. Rathi, S. Maurer, G. Kubik and D. Summerer*

Isolation of human genomic DNA sequences with expanded nucleobase selectivity

J. Am. Chem. Soc., 2016,138, 9910-18.

  

57. P. Roser, M. J. Schmidt, M. Drescher* and D. Summerer*

Site-directed spin labeling of proteins for distance measurements in vitro and in cells

Org. Biomol. Chem., 2016,14, 5468-76.

  

56.G. Kubik and D. Summerer*

TALEored epigenetics: a DNA-binding scaffold for programmable epigenome editing and analysis

ChemBioChem., 2016,17, 975-80.

  

55. D. Summerer*, M. Giess, S. Maurer, G. Kubik

Transcription activator-like effector (TALE)-based decoding of cytosine nucleobases by selective modification response

Patent application., 2016, filed by the University of Konstanz.

   

54. M. J. Schmidt, A. Fedoseev, D. Bücker, J. Borbas, C. Peter, M. Drescher* and D. Summerer*

EPR Distance measurements in native proteins with genetically encoded spin labels

ACS Chem. Biol., 2015, 18, 2764-71.

 

53. D. Summerer*

N6-Methyladenine: a potential epigenetic mark in eukaryotic genomes

Angew. Chem. Int. Ed., 2015, 54, 10714-6.

 

52. M. J. Schmidt, A. Fedoseev, D. Summerer* and M. Drescher*

Genetically encoded spin labels for in vitro and in-cell EPR studies of native proteins

Methods Enzymol., 2015, 563, 483-502.

  

51. G. Kubik and D. Summerer*

Deciphering epigenetic cytosine modifications by direct molecular recognition

ACS Chem. Biol., 2015, 10, 1580-9.

 

50. G. Kubik, S. Batke and D. Summerer*

Programmable sensors of 5-hydroxymethylcytosine

J. Am. Chem. Soc., 2015, 137, 2-5.

 

49. G. Kubik and D. Summerer*

Achieving single nucleotide resolution of 5-methylcytosine detection with TALEs

ChemBioChem., 2015, 16, 228-31.

 

48. B. Klauser, C. Rehm, D. Summerer and J. S. Hartig

Engineering of ribozyme-based aminoglycoside switches of gene expression by in vivo genetic selection in Saccharomyces

cerevisiae

Methods Enzymol., 2015, 550, 301-20.

 

47. D. Summerer, M. J. Schmidt, M. Drescher

Genetically encoded spin label

Patent application, 2015, PCT/EP2015/050568, filed by the University of Konstanz

 

46. M. Pott, M. J. Schmidt and D. Summerer*

Evolved sequence contexts for highly efficient amber suppression with noncanonical amino acids

ACS Chem. Biol., 2014, 9, 2815-22.

 

45. G. Kubik, M. J. Schmidt, J. E. Penner and D. Summerer*

Programmable and highly resolved in vitro detection of genomic 5-methylcytosine by TALEs

Angew. Chem. Int. Ed., 2014, 53, 6002-6.

University press release (german)

 

44. M. J. Schmidt, A. Weber, M. Pott, W. Welte and D. Summerer*

Structural basis of furan-amino acid recognition by a polyspecific aminoacyl-tRNA-synthetase and its genetic

encoding in human cells

ChemBioChem, 2014, 15, 1755-60.

 

43. M. J. Schmidt and D. Summerer*

Genetic code expansion as a tool to study regulatory processes of transcription

Front. Chem., 2014, 2 (7), 1-11.

 

42. M. J. Schmidt, J. Borbas, M. Drescher* and D. Summerer*

A genetically encoded spin label for electron paramagnetic resonance distance measurements

J. Am. Chem. Soc., 2014, 136, 1238-41.

University press release (german)

Three times highlighted by Faculty of 1000 (including rating: “exceptional”)

Congratulations to M. J. Schmidt for receiving the Ernst Award of the GDCh for this study!

 

41. D. Summerer, M. J. Schmidt

Intercalating amino acids

Patent application, 2014, PCT/EP2014/065601, filed by the University of Konstanz

 

40. D. Summerer, G. Kubik, M. J. Schmidt

Direct, programmable detection of epigenetic cytosine modifications using TAL effectors

Patent application, 2014, PCT/EP2014/001753, filed by the University of Konstanz

 

39. M. J. Schmidt, D. Summerer*

Red-light-controlled protein-RNA crosslinking with a genetically encoded furan

Angew. Chem. Int. Ed., 2013, 52, 4690-93.

 

38. M. J. Schmidt, D. Summerer*

A need for speed: genetic encoding of rapid cycloaddition chemistries for protein labelling in living cells

ChemBioChem, 2012, 13, 1553-57.

 

 

PI, Biotech Industry (Epigenetics, Genomics/Transcriptomics)

 

37. D. Summerer*

High-throughput DNA sequencing beyond the four-letter code: epigenetic modifications revealed by single

molecule bypass kinetics

ChemBioChem, 2010, 11, 2499-501

 

36. D. Summerer*, D. Hevroni, A. Jain, O. Scheck, J. Parker, A. Caruso, P.F. Stähler, C.F. Stähler and M. Beier

A flexible and fully integrated system for amplification, detection and genotyping of genomic DNA targets

based on microfluidic oligonucleotide arrays

N. Biotechnology, 2010, 27, 149-55

 

35. M. Beier, P. F. Stähler, C.F. Stähler, J. Leonhard, D. Summerer, S. Bau

Process for the investigation of nucleic acid populations

Patent application, 2010, DE102008061772A1, filed by febit holding gmbh

 

34. D. Summerer*, N. Schracke, H. Wu, Y. Cheng, S. Bau, C.F. Stähler, P.F. Stähler and M. Beier

Targeted enrichment of cancer-related gene exons with a flexible and fully automated microarray platform

Genomics, 2010, 95, 241-6

 

33. C.F. Stähler, P.F. Stähler, M. Beier, D. Summerer

Integrated amplification, processing and analysis of biomolecules in a microfluidic reaction medium

Patent application, 2010, WO2010043418, filed by febit holding gmbh

 

32. D. Summerer*

Enabling technologies of genomic-scale sequence enrichment for high throughput sequencing

Genomics, 2009, 94, 363-8

 

31. N. Schracke, M. Kränzle, P. F. Stähler, D. Summerer and M. Beier

Specific sequence selection and next generation resequencing of 68 E. coli genes using HybSelect

N. Biotechnology, 2009, 26, 229-33

 

30. D. Summerer*, H. Wu, B. Haase, Y. Cheng, N. Schracke, C.F. Stähler, M.S. Chee, P.F. Stähler and M. Beier

Microarray-based multicycle enrichment of genomic loci for next-generation-sequencing

Genome Res., 2009, 19, 1616-21

Described methodology was highlighted in the Faculty of 1000s magazine The Scientist: “The ten most exciting tools to

hit the life sciences in 2009″

 

29. S. Bau, N. Schracke, M. Kränzle, H. Wu, J. D. Hoheisel, P. F. Stähler, M. Beier and D. Summerer*

Targeted next-generation-sequencing by specific capture of multiple genomic loci using microfluidic

low-volume DNA arrays

Anal. Bioanal. Chem., 2009, 393, 171-5

 

28. C.F. Stähler, P.F. Stähler, M. Beier, S. Bau, D. Summerer

Flexible extraction method for the production of sequence-specific molecule libraries

Patent application, 2009, WO2009065620, filed by febit holding gmbh

 

27. C.F. Stähler, P.F. Stähler, M. Beier, D. Summerer, M. Matzas, S. Vorwerk

Improved molecular biological processing system

Patent application, 2008, WO2008080629, filed by febit holding gmbh

 

 

Postdoc, The Scripps Research Institute (Chemical Biology of RNA Translation)

 

26. D.H. Jones, S.E. Cellitti, X. Hao, Q. Zhang, M. Jahnz, D. Summerer, P.G. Schultz, T. Uno, B.H. Geierstanger

Site-specific labeling of proteins with NMR-active unnatural amino acids

J. Biomol. NMR, 2010, 46, 89-100

 

25. E.M. Tippmann, W. Liu, D. Summerer, Mack A.V. and P.G. Schultz

A genetically encoded diazirine photocrosslinker in Escherichia Coli

ChemBioChem, 2007, 8, 2210-4

 

24. E.A. Lemke§, D. Summerer§, B.H. Geierstanger, S.M. Brittain and P.G. Schultz

Control of protein phosphorylation with a genetically encoded photocaged amino acid

Nature Chem. Biol., 2007, 3, 769-72

Faculty of 1000 evaluation: factor 10, exceptional.

Highlighted in Analytical Chemistry, January 1, 2008, “Photocaged amino acids enable scientists to study phosphorylation in vivo“

Highlighted by Arnaud, CH, Chemical & Engineering News, 2007, October 31, “Modified Serine Controls Protein Phosphorylation”

Highlighted by Richards, NGJ, The HFSP Journal, 2008, 2(2), 57-60 “Shining a light on posttranslational modification”

 

23. D. Summerer, S. Chen, N. Wu, A. Deiters, J.W. Chin and P.G. Schultz

A genetically encoded, fluorescent amino acid

Proc. Nat. Acad. Sci. USA, 2006, 103, 9785-9

Faculty of 1000 evaluation: factor 8, must read

 

22. Peter G. Schultz, Alexander Deiters, Lital Alfonta, Jonathan R. Chittuluru, Dan Groff, Daniel Summerer, Meng-Lin Tsao, Jiangyun Wang, Ning Wu, Jianming Xie and Huaqiang Zeng

Orthogonal translation components for the in vivo incorporation of unnatural amino acids

Patent application, 2006, WO2006110182, filed by the Scripps Research Institute, licensed to Novartis.

 

21. M.L. Tsao, D. Summerer, P.G. Schultz

Site-Specific Incorporation of a Distance Probe into Proteins in Escherichia coli

J. Am. Chem. Soc., 2006, 128, 4572-3

 

20. A. Deiters, T.A. Cropp, D. Summerer, M. Mukherji, P.G. Schultz

Site-specific PEGylation of proteins containing unnatural amino acids

Bioorg. Med. Chem. Lett. 2004, 14, 5743-5

 

 

PhD, University of Bonn (Chemical Biology of DNA Replication)

 

19. D. Summerer*

DNA polymerase profiling

Meth. Mol. Biol., 2008, 225

 

18. D. Summerer, N.Z. Rudinger, I. Detmer, A. Marx

Enhanced fidelity of mismatch extension by DNA polymerase through directed combinatorial enzyme design

Angew. Chem. Int. Ed., 2005, 44, 4712-5

 

17. D. Summerer, A. Marx

4´-C-Ethynylthymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase

Bioorg. Med. Chem. Lett., 2005, 15, 869-71

 

16. A. Marx, Nikolas Z. Rudinger, D. Summerer

Mutated DNA Polymerases with increased mispairing discrimination

Patent application, 2005, WO2005074350, filed by the University of Bonn, licensed to Qiagen.

 

15. A. Marx, D. Summerer

Bigger DNA: New genetic helix with expanded size

Angew. Chem. Int. Ed., 2004, 43, 1625-6

 

14. M. Strerath, J. Gaster, D. Summerer, A. Marx

Increased single-nucleotide discrimination of PCR by primer probes bearing hydrophobic 4’-C-modifications

ChemBioChem, 2004, 5, 333-9

 

13. A. Marx, D. Summerer, M. Strerath

Selectivity of DNA replication

Highlights in Bioorganic Chemistry: Methods and Application, Editors: C. Schmuck, H. Wennemers, WILEY-VCH, 2004, 299-308

 

12. A. Marx, I. Detmer, J. Gaster, D. Summerer

Probing DNA polymerase function with synthetic tools

Synthesis, 2004, 1, 1-14

 

11. D. Summerer and A. Marx

4′-C-Modified nucleotides as chemical tools for investigation and modulation of DNA polymerase function

Synlett, 2004, 2, 217-24

 

10. A. Marx, M. Strerath, D. Summerer, A. Pingoud, B. Tews, M. Hahn, P. Friedhoff, J. Wilhelm

Improved method for allele-specific PCR

Patent application, 2003, WO2003072814, filed by Roche Diagnostics gmbh / Hoffmann La Roche

 

9. B. Tews, J. Wilhelm, D. Summerer, M. Strerath, A. Marx, P. Friedhoff, A. Pingoud, M. Hahn

Application of the C4´-alkylated deoxyribose primer system (CAPS) in allele specific real-time PCR for increased selectivity in discrimination of single nucleotide sequence variants

Biol. Chem. 2003, 384, 1533-41

 

8. I. Detmer, D. Summerer, A. Marx

Substrates for investigation of DNA polymerase function: synthesis and properties of 4’-C-alkylated oligonucleotides

Eur. J. Org. Chem. 2003, 10, 1837-46

 

7. I. Detmer, D. Summerer, A. Marx

DNA minor groove hydration probed with 4’-alkylated thymidines

Chem. Commun. 2002, 20, 2314-5

 

6. D. Summerer, A. Marx

A molecular beacon for quantitative monitoring of the DNA polymerase reaction in real-time

Angew. Chem. Int. Ed. 2002, 41, 3620-2

 

5. M. Strerath, D. Summerer, A. Marx

Varied DNA polymerase – sugar interactions in the nucleotide binding pocket

ChemBioChem 2002, 3, 578-80

 

4. D. Summerer, A. Marx

Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands

J. Am. Chem. Soc. 2002, 124, 910-1

 

3. A. Marx, D. Summerer

Molecular insights into error-prone DNA replication and error-free lesion bypass

ChemBioChem 2002, 3, 405-8

Highlighted by Faculty of 1000

 

2. D. Summerer, A. Marx

DNA-templated synthesis: more versatile than expected

Angew. Chem. Int. Ed. 2002, 41, 89-90

 

1. D. Summerer, A. Marx

DNA polymerase selectivity: sugar interactions monitored with high fidelity nucleotides

Angew. Chem. Int. Ed. 2001, 40, 3693-5

 

*: Corresponding Author, §: Equally Contributed