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  1. P. Koch, A. Brunschweiger, V. Namasivayam, S. Ullrich, A. Maruca, B. Lazzaretto, P. Küppers, S. Hinz, J. Hockemeyer, M. Wiese, S. Alcaro, K. Kiec-Kononowiz, C. E. Müller, "Probing substituents in the 1- and 3-position: Tetrahydropyrazino-annelated water-soluble xanthine derivatives as multi-target drugs with potent adenosine receptor antagonistic activity." Front. Chem. 2018. (in press)
  1. V. Kunig, M. Potowski, A. Gohla, A. Brunschweiger,* "DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences." Biol. Chem., 2018, 399, 691-710.



  1. M. Klika Škopić, S. Willems, B. Wagner, J. Schieven, N. Krause, A. Brunschweiger,* "Exploration of a Au(I)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles." Org. Biomol. Chem., 2017, 15, 8648-8654.

  2. M. Menzi, B. Wild, U. Pradère, A. L. Malinowska, A. Brunschweiger, H. L. Lightfoot, J. Hall, "Towards improved oligonucleotide therapeutics through faster target binding kinetics." Chem. Eur. J., 2017, 23, 14221-14230.

  3. M. Klika Škopić, H. Salamon, O. Bugain, K. Jung, A. Gohla, L. J. Doetsch, D. dos Santos, A. Bhat, B. Wagner, A. Brunschweiger,* "Acid- and Au(I)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures." Chem. Sci. 2017, 8, 3356-3361. Highlighted as inside front cover



  1. M. Klika Škopić, O. Bugain, K. Jung, S. Onstein, S. Brandherm, T. Kalliokoski, A. Brunschweiger,* "Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold." Med. Chem. Commun. 2016, 7, 1957-1965.

  2. H. Salamon, M. Klika Škopić, K. Jung, O. Bugain, A. Brunschweiger,* "Chemical biology probes from advanced DNA-encoded libraries." ACS Chem. Biol. 2016, 19, 296-307.

  3. A. Brunschweiger,* L. F. Gebert*, M. Lucic, U. Pradère, H. Jahns, J. Hunziker, J. Hall, "Site-specific conjugation of drug-like fragments to anti-miRNA oligonucleotides demonstrates pros and cons of targeting miRNAs in RISC." Chem. Commun. 2016, 52, 156-159. *joint first authors

  4. A. Brunschweiger, P. Koch, M. Schlenk, R. M, Radjainia, P. Küppers, S. Hinz, F. Pineda, M. Wiese, J. Hockemeyer, J. Heer, F. Denonne, C. E. Müller, "8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors." Bioorg. Med. Chem. 2016, 24, 5462-5480.


  1. J. Imig,*  A. Brunschweiger,* A. Brümmer, B. Guennewig, N. Mittal, S. Kishore, P. Tsikrika, A. P. Gerber, M. Zavolan, J. Hall, "MiR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction." Nat. Chem. Biol. 2015, 11, 107-114. * joint first authors


  1. A. Brunschweiger "Report from the Third Annual Symposium of the RIKEN-Max Planck Joint Research Center for Systems Chemical Biology." ACS Chem. Biol. 2014, 9, 1649-1652.

  2. A. Brunschweiger, P. Koch, M. Schlenk, F. Pineda, P. Küppers, S. Hinz, M. Köse, S. Ullrich, J. Hockemeyer, M. Wiese, J. Heer, C. E. Müller, "8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases." ChemMedChem 2014, 9, 1704-1724.


  1. P. Koch, R. Akkari, A. Brunschweiger, T. Borrmann, M. Schlenk, P. Küppers, M. Köse, H. Radjainia, J. Hockemeyer, A. Drabczyńska, K. Kieć-Kononowicz, C. E. Müller, "1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases." Bioorg. Med. Chem. 2013, 21, 7435-7452.

  2. U. Pradère, A. Brunschweiger, L. F. Gebert, M. Lucic, M. Roos M, J. Hall "Chemical Synthesis of Mono- and Bis-Labeled Pre-MicroRNAs." Angew. Chem. Int. Ed. Engl. 2013, 52, 12028-12032.

  3. M. A. Rebhan, A. Brunschweiger, J. Hall, "Measurement by SPR of Very Low Dissociation Rates: Oxidation-Mediated Loss of Biotin-Streptavidin Affinity." Chembiochem 2013, 14, 2091-2094.


  1. A. Brunschweiger, J. Hall, "A decade of the human genome sequence – how does the medicinal chemist benefit?" ChemMedChem. 2012, 7, 194-203.

  2. F. E. Loughlin, L. F. Gebert, H. Towbin, A. Brunschweiger, J. Hall, H. H.-T. Allain, "Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28" Nat. Struct. Mol. Biol. 2012, 19, 84-89.

  3. P. Ripphausen, M. Freundlieb, A. Brunschweiger, H. Zimmermann, C. E. Müller, J. Bajorath, "Identification of first-in-class inhibitors of ecto-5´-nucleotidaseJ." Med. Chem. 2012, 55, 6576-81.


  1. A. Brunschweiger, J. Iqbal, F. Umbach, A. B. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller, "Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5’-carboxamide." J. Med. Chem. 2008, 51, 4518 - 4528.


  1. A. Brunschweiger and C. E. Müller, "Medizinische Chemie der Diuretika." Pharmazie in Unserer Zeit 2006, 35, 310-320.

  2. A. Brunschweiger, J. Iqbal, A. Scheiff, M. N. Munkonda, J. Sévigny, A. F. Knowles, C. E. Müller, "Synthesis and structure-activity relationships of 5'-substituted uridine and adenosine derivatives as ectonucleotidase inhibitors." Abstract in: Purinergic Signalling 2006, 2, 170.

  3. A. Brunschweiger and C. E. Müller, "P2 Receptors activated by uracil nucleotides – an update." Curr. Med. Chem. 2006, 12, 325-348.


  1. A. Brunschweiger and D. Heber, "Two Approaches to α,α-bis-Mannich Salts of N-monosubstituted Amides." Tet. Lett. 2001, 42, 2653-2656.