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Publications

2018

  1. Koch P, Brunschweiger A, Namasivayam V, Ullrich S, Maruca A, Lazzaretto B, Küppers P, Hinz S, Hockemeyer J, Wiese M, Alcaro S, Kiec-Kononowiz5 K, Müller C E "Probing substituents in the 1- and 3-position: Tetrahydropyrazino-annelated water-soluble xanthine derivatives as multi-target drugs with potent adenosine receptor antagonistic activity" Front. Chem. 2018 [link] (in press)

2017

  1. Menzi M, Wild B, Pradère U, Malinowska AL, Brunschweiger A, Lightfoot HL, Hall J "Towards improved oligonucleotide therapeutics through faster target binding kinetics" Chemistry - A European Journal 2017 accepted [link]

  2. Klika Škopić M, Willems S, Wagner B, Schieven J, Krause N, Brunschweiger A "Exploration of a Au(I)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles" Org. Biomol. Chem. 2017 [link]

  3. Klika Škopić M, Salamon H, Bugain O, Jung K, Gohla A, Doetsch L J, dos Santos D, Bhat A, Wagner B, Brunschweiger A "Acid- and Au(I)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures" Chemical Science 2017 [link]

2016

  1. Salamon H, Škopić M K, Jung K, Bugain O, Brunschweiger A "Chemical Biology Probes from Advanced DNA-encoded Libraries" ACS Chem. Biol. 2017 [link]
  2. Brunschweiger A, Koch P, Schlenk M, Rafehi M, Radjainia H, Küppers P, Hinz S, Pineda F, Wiese M, Hockemeyer J, Heer J, Denonne F, Müller C E "8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors" Bioorganic & Medicinal Chemistry 2016 [link]

  3. Klika Škopić M, Bugain O, Jung K, Onstein S, Brandherm S, Kalliokoski T and Brunschweiger A " Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold" MedChemComm 2016 [link]

2015

  1. Brunschweiger A, Gebert L F R, Lucic M, Pradère U, Jahns H, Berk C, Hunziker J, Hall J "Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC" Chem. Commun. 2015 Oct 2015 [link]

  2. Imig J*, Brunschweiger A*, Brümmer A, Guennewig B, Mittal N, Kishore S, Tsikrika P, Gerber AP, Zavolan M, Hall J "miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction" Nat Chem Biol. 2015 Dec 22 [link] (* joint first)

2014

  1. Brunschweiger A "Report from the Third Annual Symposium of the RIKEN-Max Planck Joint Research Center for Systems Chemical Biology." ACS Chem Biol 2014 Aug 15, 9(8):1649-52 [link]

  2. Brunschweiger A, Koch P, Schlenk M, Pineda F, Küppers P, Hinz S, Köse M, Ullrich S, Hockemeyer J, Wiese M, Heer J, Müller CE "8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases." ChemMedChem Aug, 9(8):1704-24 [link]

2013

  1. Koch P, Akkari R, Brunschweiger A, Borrmann T, Schlenk M, Küppers P, Köse M, Radjainia H, Hockemeyer J, Drabczyńska A, Kieć-Kononowicz K, Müller CE "1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases." Bioorg Med Chem. 2013 Sep 25

  2. Pradère U, Brunschweiger A, Gebert LF, Lucic M, Roos M, Hall J "Chemical Synthesis of Mono- and Bis-Labeled Pre-MicroRNAs." Angew Chem Int Ed Engl. 2013 Sep 23

  3. Rebhan MA, Brunschweiger A, Hall J "Measurement by SPR of Very Low Dissociation Rates: Oxidation-Mediated Loss of Biotin-Streptavidin Affinity." Chembiochem. 2013 Sep 18

2012

  1. Ripphausen P, Freundlieb M, Brunschweiger A, Zimmermann H, Müller CE, Bajorath J "Virtual screening identifies novel sulfonamide inhibitors of ecto-5'-nucleotidase." J Med Chem. 2012 Jul 26, 55(14): 6576-81

  2. Brunschweiger A, Hall J "A decade of the human genome sequence – how does the medicinal chemist benefit?" ChemMedChem. 2012 7: 194-203

  3. Loughlin FE, Gebert LFR, Towbin H, Brunschweiger A, Hall J, Allain FHT "Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28" Nat. Struct. Mol. Biol. 2012 19: 84-89

  4. Ripphausen P, Freundlieb M, Brunschweiger A, Zimmermann H, Müller CE, Bajorath J "Identification of first-in-class inhibitors of ecto-5´-nucleotidaseJ." Med. Chem. 2012 55: 6576-81

2011

  1. Loughlin FE, Gebert LF, Towbin H, Brunschweiger A, Hall J, Allain FH "Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28." Nat Struct Mol Biol. 2011 Dec 11, 19(1):84-9

2008

  1. Brunschweiger A, Iqbal J, Umbach F, Scheiff AB, Munkonda MN, Sévigny J, Knowles AF, Müller CE, Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5’-carboxamide. J. Med. Chem. 2008 51: 4518 - 4528

2007

  1. Müller CE, Brunschweiger A, Iqbal J "Preparation of nucleotide mimetics as ectonucleotidase inhibitors." Eur. Pat. Appl. 2007 EP 1860113 A1 20071108

2006

  1. Brunschweiger A, Müller CE "P2 Receptors Activated by Uracil Nucleotides – an Update." Current Medicinal Chemistry 2006 12: 325-348

  2. Brunschweiger A, Iqbal J, Scheiff AB, Munkonda MN, Sévigny J, Knowles AF, Müller CE, Synthesis and structure-activity relationships of 5'-substituted uridine and adenosine derivatives as ectonucleotidase inhibitors. Purinergic Signalling 2006 2: 170

  3. Brunschweiger A, Müller CE "Medizinische Chemie der Diuretika." Pharmazie in Unserer Zeit 2006 35: 310-320

2001

  1. Brunschweiger A, Heber D "Two Approaches to α,α-bis-Mannich Salts of N-monosubstituted Amides." Tetrahedron Letters 2001 42: 2653-2656


    

 

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