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Position for a M.Sc. thesis

The identification of bioactive drug-like small molecules is a crucial step in drug development programs. DNA-encoded libraries of small drug-like molecules have emerged as a validated compound screening technology for hit identification.
In the research group Brunschweiger, we develop synthesis methods for DNA-encoded libraries, we synthesize proof-of-concept libraries, and we use these libraries in collaboration with biologists to identify compounds that modulate disease-relevant proteins.

Currently, we offer a project for a Master ́s thesis in the field of DNA-encoded chemistry. The candidate shall explore catalysts that are immobilized on magnetic nanoparticles for the synthesis of DNA-encoded screening libraries.

Students, who are interested in this project, send their application including CV to

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PhD Candidate Position

in DNA-encoded chemistry in a DFG-funded interdisciplinary project with researchers from TU Dortmund University and the University of Frankfurt.

In this joint research project of the research groups Brunschweiger and Koch, the candidate will design DNA-encoded libraries targeting tumor-relevant protein surfaces with state-of-the-art computational methods, develop a synthesis route for DNA-encoded libraries using synthesis methodology established in the Brunschweiger lab, and screen the libraries on tumor-relevant proteins with the aim to identify novel inhibitors.

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Contact

Dr. Andreas Brunschweiger
Tel.: 0231 755-7085